Lung protective ventilation

The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.

Though intended for EBM literature searching, PICO used here to breakdown one of earlier articles on lung protective ventilation…

Population

Patients with acute lung injury and acute respiratory distress syndrome

Intervention

Mechanical ventilation

Comparison

Traditional mechanical ventilation

– 12 mL / kg of predicted body weight

– Plateau pressure of 50 mm H20 or less

Lower tidal volumes

– 6 mL / kg of predicted body weight

– Plateau pressure of 30 mm H20 or less

Outcome

First primary outcome: Death before a pt was discharged home and was breathing without assistance

Second primary outcome: Number of days without ventilator use from day 1 to day 28

Conclusion

In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s