The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.
Though intended for EBM literature searching, PICO used here to breakdown one of earlier articles on lung protective ventilation…
Patients with acute lung injury and acute respiratory distress syndrome
Traditional mechanical ventilation
– 12 mL / kg of predicted body weight
– Plateau pressure of 50 mm H20 or less
Lower tidal volumes
– 6 mL / kg of predicted body weight
– Plateau pressure of 30 mm H20 or less
First primary outcome: Death before a pt was discharged home and was breathing without assistance
Second primary outcome: Number of days without ventilator use from day 1 to day 28
In patients with acute lung injury and the acute respiratory distress syndrome, mechanical ventilation with a lower tidal volume than is traditionally used results in decreased mortality and increases the number of days without ventilator use.